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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosisAnti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells viaBy contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studiedFurthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation.Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes.

Keywords： anti-<font style=    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract:

Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are importantHowever, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesisIn this report, we investigated the role of anti-β2GP I antibodies in complexes withThe interaction between the anti-β2GP I /β2GP I complex and plateletsOur results revealed that the anti-β2GP I /β2GP I complex was able to

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1322-1331 doi: 10.1007/s11705-021-2036-z

Abstract: For high performance supercapacitors, novel hierarchical yolk-shell -Ni(OH) /Mn O microspheres were controllably synthesized using a facile two-step method based on the solvothermal treatment. The unique -Ni(OH) based yolk-shell microstructures decorated with numerous interconnected nanosheets and the hetero-composition features can synergistically enhance reactive site exposure and electron conduction within the microspheres, facilitate charge transfer between electrolyte and electrode materials, and release structural stress during OH chemisorption/desorption. Moreover, the Mn O sediments distributed over the -Ni(OH) microspheres can serve as an effective protective layer for electrochemical reactions. Consequently, when tested in 1 mol·L KOH aqueous electrolyte for supercapacitors, the yolk-shell -Ni(OH) /Mn O microspheres exhibited a considerably high specific capacitance of 2228.6 F·g at 1 A·g and an impressive capacitance retention of 77.7% after 3000 cycles at 10 A·g . The proposed -Ni(OH) /Mn O microspheres with hetero-composition and unique hierarchical yolk-shell microstructures are highly promising to be used as electrode materials in supercapacitors and other energy storage devices.

Keywords： <font style=    

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 341-351 doi: 10.1007/s11709-017-0393-y

Abstract: Thereupon, damping ratios (<font style="font-family:Symbol">zfont>) for different types of connections

Keywords： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (<fontstyle=    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- ) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cell transplantation (allo-HSCT). High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology and were MRD-positive after allo-HSCT were studied ( =47). The MRD-positive status was considered if leukemia-associated aberrant immune phenotypes or Wilms’ tumor gene 1 expression is present in a single bone marrow sample. The cumulative incidence of the relapse and non-relapse mortality 2 years after immunotherapy were 14.5% and 21.4% ( =0.377) and 9.1% and 0.0% ( =0.985) for patients in the IFN- and chemo-DLI groups, respectively. The probability of disease-free and overall survival 2 years after immunotherapy were 76.4% and 78.6% ( =0.891) and 84.3% and 84.6% ( =0.972) for patients in the IFN- and chemo-DLI groups, respectively. Persistent MRD after immunotherapy was associated with poor survival. Thus, the MRD-directed immunotherapy was effective for patients with high-risk MDS who were MRD-positive after allo-HSCT, and the efficacy was comparable between chemo-DLI and IFN- treatment.

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-<font style=    

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Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 2,   Pages 235-238 doi: 10.1007/s11465-007-0041-7

Abstract: This paper analyzed the inverse kinematics for the new Parallel rotate slider- axes (PRS-) style hybridThe program for the PRS-XY style hybrid machining tool in accordance with the program manner for the

Keywords： numerical     accordance     transform formula     virtual     slider-    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Integrated fuzzy lectotype optimization for pile－style foundations of offshore wind turbines

Zhai Gangjun,Li Yugang,Kang Haigui

Strategic Study of CAE 2010, Volume 12, Issue 11,   Pages 40-46

Abstract:

style="text-align: justify;">Offshore wind energy is one of the most attractive sources of renewableConsidering various 13 factors of optimization objects and 4 design types of pile-style foundation, themethod has been successfully used to an offshore wind farm for the lectotype optimization of pile-style

Keywords： offshore wind turbines     pile-style foundation     lectotype optimization     fuzzy decision    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularThe response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumorsHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1Yap1 knockout enhanced anti-PD-1 efficacy.Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0722-2

Abstract: This paper proposes a novel modular cable-driven humanoid arm with anti-parallelogram mechanisms (APMs

Keywords： modular robotic arm     anti-parallelogram mechanism     Bowden cable     humanoid arm     lightweight joint design    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: review, research efforts over the past few years to mitigate the immune responses by enhancing the anti-biofoulinglayers on the biosensor surface, such as drug-releasing membranes, hydrogels, hydrophilic membranes, anti-biofoulinginformation, which is likely to aid in the research and development of novel CGM systems with profound anti-biofouling

Keywords： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 966-975 doi: 10.1007/s11705-022-2244-1

Abstract: Compared with green and blue fluorescent materials, red SPN-CDs have desirable anti-interference properties

Keywords： alkali lignin     red light carbon dots     hypochlorite     encryption and anti-counterfeiting    

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Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 174-177 doi: 10.1007/s11684-008-0032-z

Abstract: The modulatory effect of on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type 2 diabetic patients were studied. A prospective clinical trial was conducted to test the effectiveness of in selected 201 newly diagnosed type 2 diabetic patients. All patients were randomly divided into two groups: 108 with therapy and 93 without therapy. The mean follow-up period was 22 months. The blood glucose and blood pressure of all patients were under control. Serum levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) were significantly lowered and their decreased percentages were significantly higher in therapy group ( < 0.05). The number of patients with arteria iliaca intima thickening was significantly lower in group of therapy ( = 0.024). With stepwise multivariate logistic regression analysis, the decreased percentage of TG was significantly and independently related with the decreased number of patients with arteria iliaca intima thickening ( = 0.005). The study demonstrates that therapy is effective on modulating dyslipidemia in newly diagnosed type 2 diabetes patients, and may be related with the improvement of early atherosclerosis.
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Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1497-0

Abstract:

• Nanoparticle incorporation and anti-biofouling grafting were integrated

Keywords： Anti-biofouling grafting     Nanoparticle incorporation     Sterilization rates     Water flux     Water flux recovery    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: To date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalwill expand our understanding and highlight the potential widespread application of China’s homegrown anti-COVID

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Title Author Date Type Operation

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

Journal Article

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

Integrated fuzzy lectotype optimization for pile－style foundations of offshore wind turbines

Zhai Gangjun,Li Yugang,Kang Haigui

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Journal Article

A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Journal Article

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Journal Article

Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Journal Article

Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Journal Article

Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article